Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile

INOSTROZA, A.; LARA, L.; PAZ, C.; PEREZ, A.; GALLEGUILLOS, V.; HERNANDEZ, V.; BECERRA, J.; GONZÁLEZ-ROCHA, G.; SILVA, A.:
Natural Product Research 32:11 (2018) 1361-1364.

DOI: 10.1080/14786419.2017.1344655

Abstract

Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200 m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isolated from sediments of Talcahuano Bay (Chile). From the liquid culture of E. minima, we isolated Emerimicin IV, a unique fungal peptaibol that exhibited antibacterial activity. The structure of this compound was assigned by interpretation of 1H NMR and HR-LCMS data. Emerimicin IV showed bacteriostatic activity against clinical isolates of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis with MIC values ranging between 100 and 12.5 μg/mL.

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